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KMID : 1123920020160050960
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 5 p.960 ~ p.966
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Study of Repair Effect of Anti-Alzheimer on βAPP Overexpression In Neuroblastoma cell line by Ramulus et Uncus Uncariae
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Kim Sang-Ho
Kang Hyung-Won
Lyu Yeoung-Su
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Abstract
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Ramulus et Uncus Uncariae (JGD) has sweet in flavour and slightly cold in property, acting on the liver and pericardium channels. This drug was described in a medical classic as having the ability to remove ’heat’, check hyperfunction of the liver and relieve dizziness, tremors, and convulsions, and subdue ’endogenous wind’. So this study was estimated to check the anti-neuropathological effect of JGD on the Alzheimer in βAPP overexpression in neuroblastoma cell line and JGD extract was showed significantly anti-alzheimer effects (50 and 100 μg/㎖ of JGD extracts) compared with control group. Ramulus et Uncus Uncariae has anti-alzheimer effects on the βAPP overexpression in neuroblastoma cell line. So we expect that Ramulus et Uncus Uncariae may be used as a drug for neurodegenerative disease, such as stroke, Alzheimer’s disease (AD). These results indicate that Ramulus et Uncus Uncariae possess strong inhibitory effect in the nervous system of apoptosis and repair effect against the degeneration of Neuroblastoma cells by βAPP expression.
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KEYWORD
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Ramulus et Uncus Uncariae(釣鉤藤), Alzheimer, βAPP
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